Skip to main content

CAN’T STOP EATING

This documentary follows a small number of British people with an incurable genetic disease called Prader-Willi syndrome.

Prader–Willi syndrome is a rare genetic disorder in which seven genes (or some subset thereof) on chromosome 15 (q 11-13) are deleted or unexpressed (chromosome 15q partial deletion) on the paternal chromosome.

It was first described in 1956 by Andrea Prader (1919-2001), Heinrich Willi (1900-1971), Alexis Labhart (1916), Andrew Ziegler, and Guido Fanconi of Switzerland. The incidence of PWS is between 1 in 25,000 and 1 in 10,000 live births. The paternal origin of the genetic material that is affected in the syndrome is important because the particular region of chromosome 15 involved is subject to parent of origin imprinting, meaning that for a number of genes in this region only one copy of the gene is expressed while the other is silenced through imprinting. For the genes affected in PWS it is the maternal copy that is usually expressed, while the paternal copy is silenced.

This means that while most people have a single working copy of these genes, people with PWS have no working copy. PWS has the sister syndrome Angelman syndrome in which maternally derived genetic material is affected in the same genetic region.


Popular posts from this blog

The Ringworm Children

Directed by David Belhassen and Asher Hemias. The documentary won the award for "Best Documentary" at the Haifa International Film Festival and was featured as a documentary at the Israel Film Festival in Los Angeles in 2007.

In the Shadow of the Moon

Between 1968 and 1972, nine American spacecraft voyaged to the Moon, and 12 men walked upon its surface. They remain the only human beings to have stood on another world. In the Shadow of the Moon brings together for the first, and very possibly the last, time surviving crew members from every single Apollo mission which flew to the Moon, and allows them to tell their story in their own words. The definitive story of going to the moon, told by those who went. Between 1969 and 1972 an elite group of men achieved an incredible dream. They were, and remain, the only human beings to set foot on a planet other than our own. These personal testimonies are interwoven with digitally remastered footage from Nasa film archives, much of it previously unseen and all of it hauntingly evocative of a bygone era. The result is an intimate and epic film which vividly communicates the daring and the danger, the pride and the passion, of this band of special young men.

Science of Steroids

Over the better part of this century, athletes have sought to increase the natural performance of their bodies by using various means. And while most opted for the development of their muscle mass by using standard techniques, such as lifting weights, running, or other methods, some started taking to artificial substances, which rapidly promoted the growth of muscles and the expression of male traits teenage boys experienced at puberty.